Saturday, December 5, 2015

Can overweight men pass obesity risk to their children?

"Are you fat because of your dad?" is the Mail Online's bold question to its readers, explaining that "Men's weight directly affects genes in sperm linked to appetite and brain development".
This was based on a new study that found a man's weight influences the genes in his sperm.

This small study showed that DNA in the sperm of obese men differed from that of healthy weight men. The DNA itself wasn't changed, but modifications affecting how it's used by the body were.
These differences raised the possibility that children of overweight men could inherit genetic traits that make them more likely to be overweight themselves.
The researchers then looked at the sperm in six men before and after weight loss surgery, and found that the genes in their sperm changed considerably as they rapidly lost weight. This suggests that losing weight may be able to reverse the genetic changes associated with being overweight.
The results of this study are interesting, but should be treated with caution. The study only compared 13 healthy weight men with 10 overweight or obese men in the first part of the study, and just six men having weight loss surgery. These are very small numbers.
Similarly, we don't yet know whether the genetic changes identified in the overweight men will make their children more or less likely to be obese themselves, as this was not investigated in the study.
If the results of this research are confirmed in larger groups, the findings could lead to men, like women, being advised to eat healthily when trying to start a family.

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