More research is needed to unravel the complex relationship between obesity and cancer risk, including the transmission of cancer risk across generations via maternal obesity, argue two experts in a review of the current scientific evidence.
Kelle H Moley, MD, and Graham A Colditz, MD, DrPH, both of Washington University School of Medicine, St Louis, Missouri, write that, given the high levels of obesity among women of reproductive age, research efforts should focus on associated cancer risks both in their offspring and later in their lives.
"The current evidence indicates that with the exception of childhood and adolescent adiposity reducing breast cancer risk, obesity generally increases cancer risk," they say in the article, published in Science Translational Medicine on January 27.
Drs Moley and Colditz add: "Disentangling the timing of exposure to excess adiposity in relation to transmission of cancer risk across generations is a difficult task, and thus this topic remains insufficiently studied."
"However, this issue is important for future generations, as the global increase in obesity results in more pregnancies and deliveries among overweight and obese mothers."
Kelle H Moley, MD, and Graham A Colditz, MD, DrPH, both of Washington University School of Medicine, St Louis, Missouri, write that, given the high levels of obesity among women of reproductive age, research efforts should focus on associated cancer risks both in their offspring and later in their lives.
"The current evidence indicates that with the exception of childhood and adolescent adiposity reducing breast cancer risk, obesity generally increases cancer risk," they say in the article, published in Science Translational Medicine on January 27.
Drs Moley and Colditz add: "Disentangling the timing of exposure to excess adiposity in relation to transmission of cancer risk across generations is a difficult task, and thus this topic remains insufficiently studied."
"However, this issue is important for future generations, as the global increase in obesity results in more pregnancies and deliveries among overweight and obese mothers."
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